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Job Location: Rockville, MD

Power Apps Lead Architect and Developer

(ID: 2025-0961)

Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with premier research organizations and facilities including multiple institutes at the National Institutes of Health (NIH) and other public and private organizations. 

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Educational Benefits for Career Growth
  • Paid Time Off (Including Holidays)
  • Employee Referral Bonus
  • 401K Matching
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview 

The Power Apps Lead Architect and Developer will design, build, and optimize enterprise-grade solutions on Microsoft’s Power Platform, with a focus on scalable architecture, secure integrations, and performance-driven low-code applications. This role requires expert-level understanding of the Power Apps internal runtime model, Dataverse schema design, and PowerFx-based execution patterns. This position requires the ability to work onsite 5 days/week at one of our locations in Rockville, MD, Frederick MD, or Tysons, VA. 

 

 

Key Responsibilities 

  • Architect and implement Power Apps solutions that integrate seamlessly with Microsoft Dataverse, Azure services, and external APIs through standard and custom connectors.
  • Lead design of model-driven and canvas apps, governing solution layering, environment strategy, ALM pipelines, and dependency management across Dev, Test, and Prod environments.
  • Develop and maintain reusable Power Apps components, including PowerApps Component Framework (PCF) controls and custom connectors, packaged and deployed via solution manifests.
  • Oversee low-code application lifecycle management using Azure DevOps and Power Platform Build Tools, including source control of exported app JSON schemas and solution XMLs.
  • Implement PowerFx-based logic, governance policies, and performance instrumentation across Power Platform environments.
  • Collaborate with enterprise security and cloud teams to enforce compliance, data protection, and least-privilege design within Azure AD and Dataverse.
  • Guide developers in understanding internal Power Platform operations — including metadata-driven compilation, connector resolution, PowerFx expression evaluation, and runtime sandboxing within Azure Functions. 

 

Required Skills 

  • Deep expertise in Power Apps (Canvas and Model-Driven), PowerFx, and Dataverse architecture.
  • Proficiency in Power Automate, Power BI integration, and Power Platform Administration.
  • Experience building PCF components, custom connectors, and REST-based integrations.
  • Strong background in Azure Functions, Logic Apps, API Management, and Identity (AAD).
  • Familiarity with JSON, TypeScript, C#, and Power Platform CLI/Build Tools.
  • Proven experience implementing CI/CD pipelines for Power Platform solutions using Azure DevOps.
  • Ability to work onsite at one of our locations 5 days/week in Rockville, MD, Frederick, MD, or Tysons, VA.

 

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process, please contact careers@axleinfo.com

Disclaimer: The above is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job or responsibilities as needed.

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$120,000—$130,000 USD

Senior Full Stack Developer

(ID: 2025-0876)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Axle is seeking a Senior Full Stack Developer to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD.

 

Responsibilities

  • Build scalable, reliable, and flexible applications in TypeScript using NodeJS and Angular 19+

  • Design, implement, and/or use RESTful web services

  • Implement modern and responsive UI for the web and variety of devices

  • Participate in agile software development, prototyping, testing, and code reviews with a small team of developers

  • Write robust unit and end-to-end tests

 

Basic Qualifications

  • Bachelor’s Degree in Computer Science, Data Science, Bioinformatics or other related field (years of work experience will be considered in lieu of degree)

  • 3+ years experience working with TypeScript/JavaScript

  • 3+ years experience as a full-stack developer

  • Experience with the following:

    • Node.js

    • Angular 19+

    • SQL databases (PostgreSQL)

    • Containers and container orchestration tools (Docker, Kubernetes)

    • DevOps tools (Jenkins, GitHub Actions)

  • Familiarity with VCS such as Git

  • Experience with unit and end-to-end testing frameworks

  • Experience with using and leveraging GenAI technologies (i.e., CursorAI, Cline, Windsurf)

 

Relevant Skills

  • Critical thinking, problem solving, and attention to detail

  • Clear, concise communication

  • Technical writing ability

  • Familiarity working in an Agile environment

  • Attention to detail when building visually appealing and intuitive UI

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$140,000—$160,000 USD

Senior Healthcare Data Engineer

(ID: 2025-0941)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a Senior Healthcare Data Engineer to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translation Sciences (NCATS) located in Rockville, MD.

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

 

About the Mission:

Join the team at the forefront of revolutionizing medical research in the United States. We are building and maintaining the foundational infrastructure of the National Clinical Cohort Collaborative (N3C), the nation’s largest and most significant public repository of harmonized electronic health record (EHR) data. What began as a critical response to the pandemic has evolved into a multi-disease, terabyte-scale resource that empowers researchers to make discoveries faster than ever before.

This isn’t just another data engineering job. This is a chance to leave your mark on a national-scale platform, solve complex data challenges that directly impact public health, and work with a passionate team dedicated to smarter science and better treatments for all.

 

The Opportunity: Your Impact

We are looking for a visionary Senior Healthcare Data Engineer to be a lead architect of our data ingestion and harmonization ecosystem. You will be instrumental in N3C’s next evolutionary step: the transition to a scalable, secure, and flexible “Dynamic Workspaces” model. You won’t just be maintaining pipelines; you will be re-architecting, modernizing, and scaling the systems that ingest and harmonize a diverse torrent of data. From EHRs and CMS claims to cancer registries and geospatial data, you will be making it research-ready for thousands of scientists.

If you are a builder who thrives on complex challenges and wants your work to have a tangible, lasting impact on science and medicine, we want to talk to you.

 

What You’ll Do:

  • Architect and Modernize National-Scale Data Pipelines: Design, develop, and optimize robust, disease-agnostic data acquisition and ingestion pipelines built to handle the complexity and scale of N3C.
  • Master Data Integration and Harmonization: Tackle the complex challenge of harmonizing heterogeneous clinical data from countless sources. You will maintain and enhance the OMOP harmonization pipeline, improve interoperability between common data models (e.g., OMOP, PCORNet, FHIR), and ensure consistency for critical data like medications and lab values.
  • Build the Future with Dynamic Workspaces: Be a key technical player in developing the infrastructure for N3C’s new Dynamic Workspaces. You will help build the systems that provision secure, project-specific analytical environments, giving researchers access to the specific data they need while providing institutions granular control.
  • Champion Data Quality and Governance: Develop and implement sophisticated data quality frameworks, creating dashboards and feedback loops to ensure our data partners and researchers have transparent insight into data completeness, consistency, and quality.
  • Innovate with Advanced Technologies: Integrate critical new data sources, including national mortality data and CMS. You will link datasets and help build the processes for integrating novel data types like geospatial and environmental data.
  • Collaborate and Lead: Work alongside a world-class team of scientists, project managers, and engineers to translate scientific needs into technical solutions. You will provide technical leadership and mentorship, driving best practices in an agile, mission-focused environment.

 

What You’ll Bring (Required Qualifications):

  • A deep passion for using technology to solve meaningful problems in healthcare and medical research.
  • Bachelor’s or Master’s degree in Computer Science, Data Engineering, Bioinformatics, or a related field, with 8+ years of hands-on experience in data engineering (or 5+ years with a Master’s).
  • Expert-level proficiency in Python and SQL, with a proven track record of building and maintaining complex, large-scale data pipelines and ETL processes.
  • Significant experience with healthcare data is essential. You must have deep, practical knowledge of common data models (CDMs), particularly OMOP and/or FHIR, and experience with clinical terminologies (e.g., ICD, SNOMED, RxNorm).
  • Strong experience with big data technologies (e.g., Apache Spark, Hadoop) and containerization using Docker for creating reproducible and scalable workflows.
  • Proficiency with version control (Git) and CI/CD practices for data infrastructure.
  • An architectural mindset with the ability to design for scalability, reliability, and security.

 

What Sets You Apart (Preferred Qualifications):

  • Experience designing and deploying data solutions on cloud platforms (AWS, GCP, Azure).
  • Proficiency with modern workflow management systems (e.g., Nextflow, Snakemake, Airflow).
  • Experience with privacy-preserving record linkage (PPRL) techniques and the challenges of working with de-identified patient data.
  • Familiarity with federated data systems and architectures.
  • Experience working in a regulated data environment (e.g., FISMA, HIPAA).

 

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$150,000—$190,000 USD

Senior Healthcare Data Engineer

(ID: 2025-0940)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a Senior Healthcare Data Engineer to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translation Sciences (NCATS) located in Rockville, MD.

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

 

About the Mission:

Join the team at the forefront of revolutionizing medical research in the United States. We are building and maintaining the foundational infrastructure of the National Clinical Cohort Collaborative (N3C), the nation’s largest and most significant public repository of harmonized electronic health record (EHR) data. What began as a critical response to the pandemic has evolved into a multi-disease, terabyte-scale resource that empowers researchers to make discoveries faster than ever before.

This isn’t just another data engineering job. This is a chance to leave your mark on a national-scale platform, solve complex data challenges that directly impact public health, and work with a passionate team dedicated to smarter science and better treatments for all.

 

The Opportunity: Your Impact

We are looking for a visionary Senior Healthcare Data Engineer to be a lead architect of our data ingestion and harmonization ecosystem. You will be instrumental in N3C’s next evolutionary step: the transition to a scalable, secure, and flexible “Dynamic Workspaces” model. You won’t just be maintaining pipelines; you will be re-architecting, modernizing, and scaling the systems that ingest and harmonize a diverse torrent of data. From EHRs and CMS claims to cancer registries and geospatial data, you will be making it research-ready for thousands of scientists.

If you are a builder who thrives on complex challenges and wants your work to have a tangible, lasting impact on science and medicine, we want to talk to you.

 

What You’ll Do:

  • Architect and Modernize National-Scale Data Pipelines: Design, develop, and optimize robust, disease-agnostic data acquisition and ingestion pipelines built to handle the complexity and scale of N3C.
  • Master Data Integration and Harmonization: Tackle the complex challenge of harmonizing heterogeneous clinical data from countless sources. You will maintain and enhance the OMOP harmonization pipeline, improve interoperability between common data models (e.g., OMOP, PCORNet, FHIR), and ensure consistency for critical data like medications and lab values.
  • Build the Future with Dynamic Workspaces: Be a key technical player in developing the infrastructure for N3C’s new Dynamic Workspaces. You will help build the systems that provision secure, project-specific analytical environments, giving researchers access to the specific data they need while providing institutions granular control.
  • Champion Data Quality and Governance: Develop and implement sophisticated data quality frameworks, creating dashboards and feedback loops to ensure our data partners and researchers have transparent insight into data completeness, consistency, and quality.
  • Innovate with Advanced Technologies: Integrate critical new data sources, including national mortality data and CMS. You will link datasets and help build the processes for integrating novel data types like geospatial and environmental data.
  • Collaborate and Lead: Work alongside a world-class team of scientists, project managers, and engineers to translate scientific needs into technical solutions. You will provide technical leadership and mentorship, driving best practices in an agile, mission-focused environment.

 

What You’ll Bring (Required Qualifications):

  • A deep passion for using technology to solve meaningful problems in healthcare and medical research.
  • Bachelor’s or Master’s degree in Computer Science, Data Engineering, Bioinformatics, or a related field, with 8+ years of hands-on experience in data engineering (or 5+ years with a Master’s).
  • Expert-level proficiency in Python and SQL, with a proven track record of building and maintaining complex, large-scale data pipelines and ETL processes.
  • Significant experience with healthcare data is essential. You must have deep, practical knowledge of common data models (CDMs), particularly OMOP and/or FHIR, and experience with clinical terminologies (e.g., ICD, SNOMED, RxNorm).
  • Strong experience with big data technologies (e.g., Apache Spark, Hadoop) and containerization using Docker for creating reproducible and scalable workflows.
  • Proficiency with version control (Git) and CI/CD practices for data infrastructure.
  • An architectural mindset with the ability to design for scalability, reliability, and security.

 

What Sets You Apart (Preferred Qualifications):

  • Experience designing and deploying data solutions on cloud platforms (AWS, GCP, Azure).
  • Proficiency with modern workflow management systems (e.g., Nextflow, Snakemake, Airflow).
  • Experience with privacy-preserving record linkage (PPRL) techniques and the challenges of working with de-identified patient data.
  • Familiarity with federated data systems and architectures.
  • Experience working in a regulated data environment (e.g., FISMA, HIPAA).

 

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$150,000—$190,000 USD

Senior Pharmacoepidemiologist

(ID: 2025-0846)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a talented Pharmacoepidemiologist to join our team to support projects at the NIH’s National Center for Advancing Translational Sciences (NCATS). In this role, you will collaborate with clinical and data scientists, methodologists, and software engineers to develop and execute exemplar causal inference studies. You will work as a subject matter expert to create a real-world evidence (RWE) methods decision tree; support master protocol development; and support development of gold-standard guides and methodologies for conducting best practices causal inference research. You will: design, execute, and analyze studies using the National Clinical Cohort Collaborative (N3C) data; review and recommend strategies for selecting study designs to answer causal inference questions; help establish, and implement appropriate analytic value sets. 

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview:

The ideal candidate for the Pharmacoepidemiologist position is a highly skilled professional with a Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics, Causal Inference or related field. This person has experience with electronic health record and/or claims data and a strong understanding of observational study principles including: missing data handling methods; temporal research questions (cross-sectional, longitudinal); causal contrast of interest (e.g., intent-to-treat, per-protocol); effect measure of interest (e.g., risk ratio, hazard ratio); and estimands (e.g., average treatment effect, average treatment effect in the treated) of interest. Your research experience includes one or more of the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods, realized in multiple primary-author publications. Fluency with coding languages and tools is expected (i.e. SQL, Python, and R). 

 

Responsibilities: 

  • Serve as SME for RWE causal inference studies. 
  • Design and execute studies with N3C EHR data considering the following: extent of missing data; missing data handling methods; temporal component of research studies (i.e. cross-sectional, longitudinal); the causal contrast of interest (e.g., intent-to-treat, per-protocol); the effect measure of interest (e.g., risk ratio, hazard ratio); and estimand (e.g., average treatment effect, average treatment effect in the treated) of interest. 
  • Review and recommend strategies for selecting individuals in clinical cohorts. 
  • Ensure the highest data quality and minimization of bias. 
  • Use tools and languages such as Python, R, SQL, and Spark. 
  • Help establish and implement appropriate analytic value sets. 
  • Collaboratively produce extensive documentation (i.e. through training material, research protocols, open data sources such as repositories and/or methodological and research papers). 
  • Work closely with data science and software developer teams to articulate technical methods and implement decision tool strategies. 
  • Extract and transform clinical data from clinical trial and observational studies. 
  • Participate in project meetings, provide updates on progress, challenges, and mitigation strategies. 
  • Actively engage in key relevant meetings and keep abreast of emerging best practices and methods. 

 

Required Qualifications:

  • Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics or related field. 
  • Experience with the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods realized in at least 2 primary-author peer-reviewed publications, or equivalent. 
  • Ability to independently conduct statistical analysis with analytic software tools (e.g. Python, R, SQL, MatchIt/WeightIt, Matplotlib, Lifelines, SKLearn, GT-summary, statsmodels, Survey). 
  • Fluent in coding languages and tools (e.g. Python, R, SQL, Spark). 
  • Strong communication and collaboration skills, with the ability to work effectively in a multidisciplinary team. 

 

Preferred Qualifications:

  • Experience with meta-analyses and/or systematic reviews. 
  • Expertise in best practices for statistical approaches, data wrangling and visualization. 
  • Knowledge of FAIR data principles. 
  • Clinical informatics experience. 

 

 

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$135,000—$140,000 USD

Senior Software Engineer, Health Data Interoperability

(ID: 2025-0920)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a Senior Software Engineer, Health Data Interoperability to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD.

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview

Join the team at the forefront of revolutionizing medical research in the United States. We are building and maintaining the foundational infrastructure of the National Clinical Cohort Collaborative (N3C), the nation’s largest and most significant public repository of harmonized electronic health record (EHR) data. 

We believe that the future of health research depends on elegant, robust, and scalable software. Brittle, hand-coded scripts and opaque processes can’t solve the challenges of petabyte-scale clinical data. We need engineers who can think in systems, build powerful abstractions, and create the tools that will accelerate discovery for thousands of researchers nationwide.

 

The Opportunity: Your Impact

We are seeking an exceptional Senior Software Engineer to design and build the core libraries and engines that power our data interoperability and harmonization efforts. Your primary challenge will be to tame the complexity of heterogeneous health data. You won’t be writing one-off ETL scripts. You will be creating the declarative frameworks, data model transformers, and terminology mapping engines that make moving data between standards like OMOP and FHIR a systematic, reproducible, and even beautiful process

This is a role for a true craftsman. Someone who gets excited about API design, compiler theory, and building developer-centric tools. You will have the autonomy to architect foundational components from the ground up, influencing the technical direction of a project with national significance. If you want to build software that empowers scientists and enables discoveries that were previously impossible, this is your opportunity.

 

What You’ll Do:

  • Architect Core Interoperability Libraries: Design, build, and maintain high-performance libraries in Python (and potentially Rust) for mapping, transforming, and validating massive clinical datasets.
  • Develop Declarative Data Mapping Engines: Create sophisticated tools that allow domain experts to define complex data transformations using simple, clear, domain-specific languages (DSLs), separating the “what” from the “how.”
  • Build Advanced Terminology Services: Engineer libraries that handle the complex logic of mapping clinical terminologies, normalizing units of measure, and ensuring semantic consistency across disparate datasets.
  • Create Robust Data Model Abstractions: Develop strongly-typed data access layers and handlers that abstract away the underlying storage (e.g., SQL databases, Parquet files, JSON documents), presenting a unified interface for data manipulation.
  • Champion Software Engineering Excellence: Drive best practices in API design, testing, documentation, and tooling. You will produce libraries that are not only powerful but also a pleasure for other developers to use.
  • Collaborate and Innovate: Work closely with data engineers, informaticians, and scientists to understand their deepest challenges and create the foundational tools they need to succeed.

 

What You’ll Bring (Required Qualifications):

  • A profound passion for building elegant, high-quality developer tools and libraries.
  • Bachelor’s or Master’s degree in Computer Science or a related engineering field with 8+ years of professional software development experience.
  • Expert-level proficiency in Python, with deep knowledge of its object model, type system, and performance characteristics. You write clean, idiomatic, and highly testable code.
  • Proven experience designing and building libraries or frameworks for other developers. Your resume shows a history of creating successful abstractions.
  • A strong foundation in computer science fundamentals, including data structures, algorithms, and compiler/interpreter design (e.g., experience with parsing, abstract syntax trees, etc.).
  • Experience with modern software development practices: version control (Git), CI/CD, comprehensive unit testing, and meticulous documentation.

 

What Sets You Apart (Preferred Qualifications):

  • Experience with Rust. A strong interest or professional experience in Rust is highly desirable for performance-critical components.
  • Deep experience with healthcare data and a clear understanding of the challenges posed by standards like OMOP, FHIR, and other Common Data Models.
  • Experience building and working with Domain-Specific Languages (DSLs).
  • Expertise in building high-performance data processing systems and a keen eye for optimization.
  • Contributions to open-source software libraries and frameworks.

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$130,000—$169,000 USD

IT Program Manager

(ID: 2025-0917)

Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with premier research organizations and facilities including multiple institutes at the National Institutes of Health (NIH) and other public and private organizations. 

 

Axle is currently hiring a dynamic, driven, and solution oriented IT Program Manager in Rockville, MD to lead the integration and management of authorization solutions.

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Educational Benefits for Career Growth
  • Paid Time Off (Including Holidays)
  • Employee Referral Bonus
  • 401K Matching
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview

We are seeking a skilled IT Program Manager to lead complex programs, ensuring on-time delivery, contract compliance, and strong client relationships. This role combines program leadership with expertise in federal contracting and authorization solutions to drive mission success. 

 

Responsibilities

  • Manage the full lifecycle of government-sponsored programs, ensuring on-time, within-budget delivery and adherence to scope and deliverables.
  • Lead the integration and management of authorization solutions, with a focus on overseeing Software-as-a-Service system delivery and support for secure, compliant access across users, systems, and datasets.
  • Develop project plans, track milestones, and coordinate cross-functional teams to deliver scientific, technical, and administrative support services.
  • Monitor compliance with federal contract requirements, policies, and reporting standards.
  • Serve as the primary point of contact for government clients, building and maintaining strong client relationships by anticipating needs, addressing concerns, and providing strategic guidance.
  • Translate client objectives into actionable plans and ensure solutions align with mission outcomes.
  • Support growth by identifying new opportunities within existing contracts and accounts.
  • Partner with technical staff to evaluate, recommend, and implement authorization and identity management frameworks, including software enhancements and related access control systems.
  • Ensure adherence to government security and privacy requirements, supporting audits, compliance activities, and reporting specific to authorization platforms.
  • Prepare progress reports, briefings, and presentations for federal sponsors and internal leadership.
  • Track program performance metrics and recommend improvements for efficiency and effectiveness.
  • Manage budgets, staffing plans, and subcontractor performance as needed.

 

Qualifications

  • Strong knowledge of authorization and identity management solutions, including demonstrated experience managing government access control frameworks.
  • 5+ years of program management or account management experience with federal government clients.
  • Demonstrated success leading multi-disciplinary teams in a government contracting environment.
  • Experience with NIH institutes strongly preferred.
  • Proven track record in federal contract management and client relationship management.
  • Excellent communication, negotiation, and stakeholder management skills.
  • Bachelor’s degree in business administration, public administration, computer science, or related field.
  • PMP, CSM, or similar certifications desirable.

 

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process, please contact careers@axleinfo.com

Disclaimer: The above is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job or responsibilities as needed.

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$140,000—$160,000 USD

IT Operations Technical Lead

(ID: 2025-0916)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a IT Operations Technical Lead to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translation Sciences (NCATS) located in Rockville, MD.

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview

In this role, you will have the opportunity to design, implement, secure and enhance our on-prem and cloud infrastructure and systems. Your experience with IT Operations and Cloud Application support will be used to create roadmaps for operational efficiency, and maintenance. Working alongside other operations teams and development engineering teams, you will collaborate with colleagues and client team members supporting network and architecture assessment, Authorization to Operate (ATO), threat modeling, vulnerability assessment, and security operations. 

 

Responsibilities

  • Oversee On-Prem & Cloud daily technical operations
  • Apply appropriate security measures to safeguard government systems by implementing industry-standard best practices adequately and NIH-mandated
  • Assume a technical lead role in the administration and management of infrastructure solutions that are deployed on-prem and in all major cloud service provides in accordance with Security Guidelines
  • Installing, configuring, maintaining, and supporting applications and servers
  • Performing operating system and software installation, testing, patching and upgrades
  • Monitoring the Heath of internal environment and connections
  • Research new technologies that are applicable to current projects and make recommendations to improve performance, optimize operations, and reduce costs
  • Architecting and leading the migration of legacy On-Prem solution migrations to Cloud Environments with High Performance and reliability
  • Assist in managing technology in projects and providing technical guidance or solutions for task completion
  • Participate in technical discussions or review as a technical consultant for solutions feasibility studies (technical alternatives, best packages, supporting architecture best practices, technical risks, breakdown into components, estimations)
  • Continuously collaborate with the Software Development teams in addressing Operational technical debt
  • Conduct periodic security checks/audits in to ensure Environment compliance with Government guidance and directives
  • Develop and guide team members in enhancing their technical capabilities and increasing productivity

 

Qualifications

  • 8+ years of IT Operations experience
  • 5+ years of supporting Cloud Services (AWS, Azure, GCP)
  • Bachelor’s degree in computer science, engineering, or similar field
  • Experience working with and securing cloud services such as AWS EC2, EKS, GuardDuty, ELB, ECS, IAM, S3, RDS, CloudTrail, CloudFront, and AWS Config
  • Experience assessing the security of the cloud and Kubernetes environments
  • Knowledge of ITSM tools such as ServiceNow or Remedy
  • Demonstrated knowledge preparing guidance related to Cybersecurity best practices within the framework of NIST publications, ISO 2700 Series, CIS, OWASP, RMF, and the various control families within
  • Experience configuring and maintaining monitoring tools, SIEM’s, IDSs, IPS, etc.
  • Experience with a programming or scripting language such as Ruby, Go, or Python
  • Knowledgeable on zero trust architecture concepts such as Google BeyondCorp

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$140,000—$160,000 USD

Financial & Systems Analyst

(ID: 2025-0904)

Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with premier research organizations and facilities including multiple institutes at the National Institutes of Health (NIH) and other public and private organizations. 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Educational Benefits for Career Growth
  • Paid Time Off (Including Holidays)
  • Employee Referral Bonus
  • 401K Matching
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

Overview:

We are seeking a motivated Financial & Systems Analyst to support our finance and accounting operations while helping improve financial systems and processes. This role blends financial analysis with technology-driven process improvement to ensure accurate reporting, efficient workflows, and reliable decision-making support.

The ideal candidate has a strong foundation in financial principles, enjoys working with data, and is eager to learn new tools and systems. This position is based in Rockville, MD 5 days/week. 

Responsibilities:

  • Collect, organize, and analyze financial data to prepare accurate reports.
  • Assist with budgeting, forecasting, and variance analysis.
  • Support monthly, quarterly, and annual reporting cycles.
  • Help monitor company performance metrics and hihlight trends or discrepancies.
  • Work with accounting staff on reconciliations, general ledger support, and compliance with GAAP and FAR/DCAA requirements.
  • Support the use and optimization of financial systems including Deltek Vantagepoint and Microsoft Dynamics.
  • Create dashboards and reports in Power BI to track KPIs and financial performance.
  • Assist with automating workflows using Power Automate and other tools to reduce manual effort.
  • Help document financial processes and recommend improvements for efficiency and accuracy.
  • Collaborate with IT and Finance teams to troubleshoot system issues and support integrations.

Qualifications:

  • Bachelor’s degree in Finance, Accounting, Information Systems, or related field.
  • 2-4 years of experience in financial analysis, accounting, or systems/process improvement (internships or co-op experience welcome).
  • Familiarity with financial ERP systems (Deltek, Microsoft Dynamics, or similar).
  • Hands-on experience with Power BI, Excel, or automation tools is a plus.
  • Strong attention to detail and ability to analyze data for accuracy.
  • Excellent communication and collaboration skills.
  • Eagerness to learn and grow in both financial and systems-focused areas.
  • Ability to work in Rockville, MD 5 days/week 

This role is perfect for someone who wants to gain experience in both finance and financial systems while supporting process improvements and working closely with senior analysts and leadership.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process, please contact careers@axleinfo.com

Disclaimer: The above is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job or responsibilities as needed.

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

Salary Range
$80,000—$100,000 USD

Pharmacoepidemiologist, Causal Inference

(ID: 2025-0803)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a talented Pharmacoepidemiologist to join our team to support projects at the NIH’s National Center for Advancing Translational Sciences (NCATS). In this role, you will collaborate with clinical and data scientists, methodologists, and software engineers to develop and execute exemplar causal inference studies. You will work as a subject matter expert to create a real-world evidence (RWE) methods decision tree; support master protocol development; and support development of gold-standard guides and methodologies for conducting best practices causal inference research. You will: design, execute, and analyze studies using the National Clinical Cohort Collaborative (N3C) data; review and recommend strategies for selecting study designs to answer causal inference questions; help establish, and implement appropriate analytic value sets. 

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

 

Overview:

The ideal candidate for the Pharmacoepidemiologist position is a highly skilled professional with a Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics, Causal Inference or related field. This person has experience with electronic health record and/or claims data and a strong understanding of observational study principles including: missing data handling methods; temporal research questions (cross-sectional, longitudinal); causal contrast of interest (e.g., intent-to-treat, per-protocol); effect measure of interest (e.g., risk ratio, hazard ratio); and estimands (e.g., average treatment effect, average treatment effect in the treated) of interest. Your research experience includes one or more of the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods, realized in multiple primary-author publications. Fluency with coding languages and tools is expected (i.e. SQL, Python, and R). 

 

Responsibilities: 

  • Serve as SME for RWE causal inference studies. 

  • Design and execute studies with N3C EHR data considering the following: extent of missing data; missing data handling methods; temporal component of research studies (i.e. cross-sectional, longitudinal); the causal contrast of interest (e.g., intent-to-treat, per-protocol); the effect measure of interest (e.g., risk ratio, hazard ratio); and estimand (e.g., average treatment effect, average treatment effect in the treated) of interest. 

  • Review and recommend strategies for selecting individuals in clinical cohorts. 

  • Ensure the highest data quality and minimization of bias. 

  • Use tools and languages such as Python, R, SQL, and Spark. 

  • Help establish and implement appropriate analytic value sets. 

  • Collaboratively produce extensive documentation (i.e. through training material, research protocols, open data sources such as repositories and/or methodological and research papers). 

  • Work closely with data science and software developer teams to articulate technical methods and implement decision tool strategies. 

  • Extract and transform clinical data from clinical trial and observational studies. 

  • Participate in project meetings, provide updates on progress, challenges, and mitigation strategies. 

  • Actively engage in key relevant meetings and keep abreast of emerging best practices and methods. 

 

Required Qualifications:

  • Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics or related field. 

  • Experience with the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods realized in at least 2 primary-author peer-reviewed publications, or equivalent. 

  • Ability to independently conduct statistical analysis with analytic software tools (e.g. Python, R, SQL, MatchIt/WeightIt, Matplotlib, Lifelines, SKLearn, GT-summary, statsmodels, Survey). 

  • Fluent in coding languages and tools (e.g. Python, R, SQL, Spark). 

  • Strong communication and collaboration skills, with the ability to work effectively in a multidisciplinary team. 

 

Preferred Qualifications:

  • Experience with meta-analyses and/or systematic reviews. 

  • Expertise in best practices for statistical approaches, data wrangling and visualization. 

  • Knowledge of FAIR data principles. 

  • Clinical informatics experience. 

 

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#INDPSD

Salary Range
$135,000—$140,000 USD