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Job Location: Rockville, MD

Scientific Program Manager – High Containment Laboratory

(2025-LU15) 

 

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

 

Position Overview

Axle is seeking an experienced Scientific Program Manager with proven expertise in high-containment laboratory operations (BSL-3 and BSL-4 environments) to support financial, operational, and research management. This role involves managing complex resources, ensuring biosafety compliance, and supporting mission-critical research projects that drive innovation in global health and biotechnology.

 

Key Responsibilities

  • Lead and support initiatives related to biosafety, biosecurity, and regulatory management in high- and maximum-containment (BSL-3/ABSL-3 and BSL-4/ABSL-4) laboratories.
  • Collaborate with institutional safety offices, emergency response teams, and security personnel to maintain compliance and ensure safe, continuous operations.
  • Provide expert guidance on containment facility operations, policies, and emergency preparedness.
  • Assist with managing budget allocations, planning, supplemental reviews, initiatives, program changes, and end-of-year spending.
  • Contribute to the development of resource packages for new investigators.
  • Support resource management efforts, including personnel, funding, and space allocations.
  • Advise leadership on reporting requirements, data calls, and strategic resource planning.
  • Offer recommendations for laboratory and research facility operations, including planning and coordinating space for new projects, programs, or renovations.
  • Maintain accurate records and databases of laboratory space, usage, and capacity.
  • Provide input on policies, technical design, construction, and operational needs for research environments.
  • Track and manage renovations, new construction, and facility improvement projects.
  • Make informed recommendations to leadership on scientific and logistical requirements for renovation and resource requests.
  • Provide support for vaccine development and translational research projects, including production and testing of clinical materials.
  • Collaborate with principal investigators and institutional offices on intellectual property, technology transfer, and licensing matters.
  • Contribute to strategic planning, assessment of new scientific initiatives, and resource allocation decisions.

 

Qualifications and Skills

  • Bachelor’s or Master’s degree in biological sciences, engineering, public health, or a related field; advanced degree preferred.
  • 2-5+ years of experience supporting operations or safety within a BSL-3 or BSL-4 research environment.
  • Strong organizational and project management skills, with the ability to manage multiple priorities effectively.
  • Excellent communication and collaboration abilities, with experience working across multidisciplinary teams.
  • Proven ability to problem-solve in fast-paced, highly regulated environments, demonstrating adaptability and sound judgment.

 

 

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

 

Salary Range
$110,000—$125,000 USD

Senior Pharmacoepidemiologist

(ID: 2025-0846)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a talented Pharmacoepidemiologist to join our team to support projects at the NIH’s National Center for Advancing Translational Sciences (NCATS). In this role, you will collaborate with clinical and data scientists, methodologists, and software engineers to develop and execute exemplar causal inference studies. You will work as a subject matter expert to create a real-world evidence (RWE) methods decision tree; support master protocol development; and support development of gold-standard guides and methodologies for conducting best practices causal inference research. You will: design, execute, and analyze studies using the National Clinical Cohort Collaborative (N3C) data; review and recommend strategies for selecting study designs to answer causal inference questions; help establish, and implement appropriate analytic value sets. 

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview:

The ideal candidate for the Pharmacoepidemiologist position is a highly skilled professional with a Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics, Causal Inference or related field. This person has experience with electronic health record and/or claims data and a strong understanding of observational study principles including: missing data handling methods; temporal research questions (cross-sectional, longitudinal); causal contrast of interest (e.g., intent-to-treat, per-protocol); effect measure of interest (e.g., risk ratio, hazard ratio); and estimands (e.g., average treatment effect, average treatment effect in the treated) of interest. Your research experience includes one or more of the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods, realized in multiple primary-author publications. Fluency with coding languages and tools is expected (i.e. SQL, Python, and R). 

 

Responsibilities: 

  • Serve as SME for RWE causal inference studies. 
  • Design and execute studies with N3C EHR data considering the following: extent of missing data; missing data handling methods; temporal component of research studies (i.e. cross-sectional, longitudinal); the causal contrast of interest (e.g., intent-to-treat, per-protocol); the effect measure of interest (e.g., risk ratio, hazard ratio); and estimand (e.g., average treatment effect, average treatment effect in the treated) of interest. 
  • Review and recommend strategies for selecting individuals in clinical cohorts. 
  • Ensure the highest data quality and minimization of bias. 
  • Use tools and languages such as Python, R, SQL, and Spark. 
  • Help establish and implement appropriate analytic value sets. 
  • Collaboratively produce extensive documentation (i.e. through training material, research protocols, open data sources such as repositories and/or methodological and research papers). 
  • Work closely with data science and software developer teams to articulate technical methods and implement decision tool strategies. 
  • Extract and transform clinical data from clinical trial and observational studies. 
  • Participate in project meetings, provide updates on progress, challenges, and mitigation strategies. 
  • Actively engage in key relevant meetings and keep abreast of emerging best practices and methods. 

 

Required Qualifications:

  • Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics or related field. 
  • Experience with the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods realized in at least 2 primary-author peer-reviewed publications, or equivalent. 
  • Ability to independently conduct statistical analysis with analytic software tools (e.g. Python, R, SQL, MatchIt/WeightIt, Matplotlib, Lifelines, SKLearn, GT-summary, statsmodels, Survey). 
  • Fluent in coding languages and tools (e.g. Python, R, SQL, Spark). 
  • Strong communication and collaboration skills, with the ability to work effectively in a multidisciplinary team. 

 

Preferred Qualifications:

  • Experience with meta-analyses and/or systematic reviews. 
  • Expertise in best practices for statistical approaches, data wrangling and visualization. 
  • Knowledge of FAIR data principles. 
  • Clinical informatics experience. 

 

 

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$135,000—$140,000 USD

Senior Software Engineer, Health Data Interoperability

(ID: 2025-0920)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a Senior Software Engineer, Health Data Interoperability to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD.

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview

Join the team at the forefront of revolutionizing medical research in the United States. We are building and maintaining the foundational infrastructure of the National Clinical Cohort Collaborative (N3C), the nation’s largest and most significant public repository of harmonized electronic health record (EHR) data. 

We believe that the future of health research depends on elegant, robust, and scalable software. Brittle, hand-coded scripts and opaque processes can’t solve the challenges of petabyte-scale clinical data. We need engineers who can think in systems, build powerful abstractions, and create the tools that will accelerate discovery for thousands of researchers nationwide.

 

The Opportunity: Your Impact

We are seeking an exceptional Senior Software Engineer to design and build the core libraries and engines that power our data interoperability and harmonization efforts. Your primary challenge will be to tame the complexity of heterogeneous health data. You won’t be writing one-off ETL scripts. You will be creating the declarative frameworks, data model transformers, and terminology mapping engines that make moving data between standards like OMOP and FHIR a systematic, reproducible, and even beautiful process

This is a role for a true craftsman. Someone who gets excited about API design, compiler theory, and building developer-centric tools. You will have the autonomy to architect foundational components from the ground up, influencing the technical direction of a project with national significance. If you want to build software that empowers scientists and enables discoveries that were previously impossible, this is your opportunity.

 

What You’ll Do:

  • Architect Core Interoperability Libraries: Design, build, and maintain high-performance libraries in Python (and potentially Rust) for mapping, transforming, and validating massive clinical datasets.
  • Develop Declarative Data Mapping Engines: Create sophisticated tools that allow domain experts to define complex data transformations using simple, clear, domain-specific languages (DSLs), separating the “what” from the “how.”
  • Build Advanced Terminology Services: Engineer libraries that handle the complex logic of mapping clinical terminologies, normalizing units of measure, and ensuring semantic consistency across disparate datasets.
  • Create Robust Data Model Abstractions: Develop strongly-typed data access layers and handlers that abstract away the underlying storage (e.g., SQL databases, Parquet files, JSON documents), presenting a unified interface for data manipulation.
  • Champion Software Engineering Excellence: Drive best practices in API design, testing, documentation, and tooling. You will produce libraries that are not only powerful but also a pleasure for other developers to use.
  • Collaborate and Innovate: Work closely with data engineers, informaticians, and scientists to understand their deepest challenges and create the foundational tools they need to succeed.

 

What You’ll Bring (Required Qualifications):

  • A profound passion for building elegant, high-quality developer tools and libraries.
  • Bachelor’s or Master’s degree in Computer Science or a related engineering field with 8+ years of professional software development experience.
  • Expert-level proficiency in Python, with deep knowledge of its object model, type system, and performance characteristics. You write clean, idiomatic, and highly testable code.
  • Proven experience designing and building libraries or frameworks for other developers. Your resume shows a history of creating successful abstractions.
  • A strong foundation in computer science fundamentals, including data structures, algorithms, and compiler/interpreter design (e.g., experience with parsing, abstract syntax trees, etc.).
  • Experience with modern software development practices: version control (Git), CI/CD, comprehensive unit testing, and meticulous documentation.

 

What Sets You Apart (Preferred Qualifications):

  • Experience with Rust. A strong interest or professional experience in Rust is highly desirable for performance-critical components.
  • Deep experience with healthcare data and a clear understanding of the challenges posed by standards like OMOP, FHIR, and other Common Data Models.
  • Experience building and working with Domain-Specific Languages (DSLs).
  • Expertise in building high-performance data processing systems and a keen eye for optimization.
  • Contributions to open-source software libraries and frameworks.

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$130,000—$169,000 USD

Senior Project Manager

(ID: 2025-0901)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a Senior Project Manager to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD.

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview

As a Project Manager at Axle, you will lead complex, cross-functional initiatives aligned with our strategic mission to lead advances in research, clinical practice and personalized medicine. You will be responsible for guiding healthcare, research, and technology projects from conception through delivery, ensuring they are completed on time, on budget, within scope, and aligned with organizational goals.  The project manager will join a national, highly interactive, supportive, and interdisciplinary group of technologists, researchers and information experts that will support the development of approaches that derive insights from data. 

 

Key Responsibilities:

  • Lead and execute strategic initiatives spanning healthcare operations, population health analytics, biomedical research innovation, and cloud/cybersecurity technology solutions. 
  • Guide project teams to deliver on time, with clarity, quality, and a measurable impact.
  • Manage a geographically-distributed and interdisciplinary project.
  • Create project plans, manage deliverables, including timelines, risk identification and mitigation and coordination of cross-functional tasks using project management software (Smartsheet, Jira).
  • Lead, mentor and coordinate internal teams and external stakeholders.
  • Guide junior project managers and team members, fostering collaboration and continuous improvement.
  • Maintain regular, transparent communications and status updates.
  • Manage complex stakeholder expectations across clients, internal leadership, and external partners in healthcare and research domains. 
  • Identify, schedule and organize appropriate and effective meetings for various activities. Manage meetings to make progress on projects. Assist with goal-oriented agendas, coordinate slides for presentations, facilitate meetings, capture purpose-delivered action items and decisions and distribute information to the attendees.
  • Drive adoption of new tools, practices, or workflows across projects.
  • Conduct post-project evaluations, document lessons learned, and share best practices.

 

Required Skills:

  • Experience with managing virtual teams
  • Familiar with waterfall and agile methodologies
  • Meticulous organization (e.g. document and information management skills)
  • Ability to be self-directed, anticipate business unit needs, take initiative, and work well in a cross-functional and interdisciplinary team
  • Remains positive and calm under pressure
  • Collaborates and works with diverse team members of all levels with utmost professionalism
  • Strong interpersonal skills with excellent oral, written and verbal communication skills
  • Proficiency with MS Office and Google Drive 
  • Project management software (Smartsheet, Jira)

 

Minimum Education: Bachelor’s degree

Experience: 5–7+ years of experience in senior project management roles, with a proven track record in large-scale, high-impact programs. Experience in healthcare IT, biomedical research, or cloud/cybersecurity domains is a strong plus.

Preferred Skills: PMP, PRINCE2, Scrum, Agile, Informatics.  

Supervision Received: Work is performed under the direction of the Program Manager and Director

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

 

Salary Range
$125,000—$150,000 USD

IT Program Manager

(ID: 2025-0917)

Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with premier research organizations and facilities including multiple institutes at the National Institutes of Health (NIH) and other public and private organizations. 

 

Axle is currently hiring a dynamic, driven, and solution oriented IT Program Manager in Rockville, MD.

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Educational Benefits for Career Growth
  • Paid Time Off (Including Holidays)
  • Employee Referral Bonus
  • 401K Matching
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview

We are seeking a skilled IT Program Manager to lead complex programs, ensuring on-time delivery, contract compliance, and strong client relationships. This role combines program leadership with expertise in federal contracting and authorization solutions to drive mission success. 

 

Responsibilities

  • Manage the full lifecycle of government-sponsored programs, ensuring on-time, within-budget delivery and adherence to scope and deliverables.
  • Develop project plans, track milestones, and coordinate cross-functional teams to deliver scientific, technical, and administrative support services.
  • Monitor compliance with federal contract requirements, policies, and reporting standards.
  • Serve as the primary point of contact for government clients, building and maintaining strong client relationships by anticipating needs, addressing concerns, and providing strategic guidance.
  • Translate client objectives into actionable plans and ensure solutions align with mission outcomes.
  • Support growth by identifying new opportunities within existing contracts and accounts.
  • Lead the integration and management of authorization solutions, with a focus on overseeing Software-as-a-Service system delivery and support for secure, compliant access across users, systems, and datasets.
  • Partner with technical staff to evaluate, recommend, and implement authorization and identity management frameworks, including software enhancements and related access control systems.
  • Ensure adherence to government security and privacy requirements, supporting audits, compliance activities, and reporting specific to authorization platforms.
  • Prepare progress reports, briefings, and presentations for federal sponsors and internal leadership.
  • Track program performance metrics and recommend improvements for efficiency and effectiveness.
  • Manage budgets, staffing plans, and subcontractor performance as needed.

 

Qualifications

  • Bachelor’s degree in business administration, public administration, computer science, or related field.
  • 5+ years of program management or account management experience with federal government clients.
  • Demonstrated success leading multi-disciplinary teams in a government contracting environment.
  • Experience with NIH institutes strongly preferred.
  • Strong knowledge of authorization and identity management solutions, including demonstrated experience managing government access control frameworks.
  • Proven track record in federal contract management and client relationship management.
  • Excellent communication, negotiation, and stakeholder management skills.
  • PMP, CSM, or similar certifications desirable.

 

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process, please contact careers@axleinfo.com

Disclaimer: The above is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job or responsibilities as needed.

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$140,000—$160,000 USD

IT Operations Technical Lead

(ID: 2025-0916)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a IT Operations Technical Lead to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translation Sciences (NCATS) located in Rockville, MD.

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview

In this role, you will have the opportunity to design, implement, secure and enhance our on-prem and cloud infrastructure and systems. Your experience with IT Operations and Cloud Application support will be used to create roadmaps for operational efficiency, and maintenance. Working alongside other operations teams and development engineering teams, you will collaborate with colleagues and client team members supporting network and architecture assessment, Authorization to Operate (ATO), threat modeling, vulnerability assessment, and security operations. 

 

Responsibilities

  • Oversee On-Prem & Cloud daily technical operations
  • Apply appropriate security measures to safeguard government systems by implementing industry-standard best practices adequately and NIH-mandated
  • Assume a technical lead role in the administration and management of infrastructure solutions that are deployed on-prem and in all major cloud service provides in accordance with Security Guidelines
  • Installing, configuring, maintaining, and supporting applications and servers
  • Performing operating system and software installation, testing, patching and upgrades
  • Monitoring the Heath of internal environment and connections
  • Research new technologies that are applicable to current projects and make recommendations to improve performance, optimize operations, and reduce costs
  • Architecting and leading the migration of legacy On-Prem solution migrations to Cloud Environments with High Performance and reliability
  • Assist in managing technology in projects and providing technical guidance or solutions for task completion
  • Participate in technical discussions or review as a technical consultant for solutions feasibility studies (technical alternatives, best packages, supporting architecture best practices, technical risks, breakdown into components, estimations)
  • Continuously collaborate with the Software Development teams in addressing Operational technical debt
  • Conduct periodic security checks/audits in to ensure Environment compliance with Government guidance and directives
  • Develop and guide team members in enhancing their technical capabilities and increasing productivity

 

Qualifications

  • 8+ years of IT Operations experience
  • 5+ years of supporting Cloud Services (AWS, Azure, GCP)
  • Bachelor’s degree in computer science, engineering, or similar field
  • Experience working with and securing cloud services such as AWS EC2, EKS, GuardDuty, ELB, ECS, IAM, S3, RDS, CloudTrail, CloudFront, and AWS Config
  • Experience assessing the security of the cloud and Kubernetes environments
  • Knowledge of ITSM tools such as ServiceNow or Remedy
  • Demonstrated knowledge preparing guidance related to Cybersecurity best practices within the framework of NIST publications, ISO 2700 Series, CIS, OWASP, RMF, and the various control families within
  • Experience configuring and maintaining monitoring tools, SIEM’s, IDSs, IPS, etc.
  • Experience with a programming or scripting language such as Ruby, Go, or Python
  • Knowledgeable on zero trust architecture concepts such as Google BeyondCorp

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$140,000—$160,000 USD

Financial & Systems Analyst

(ID: 2025-0904)

Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with premier research organizations and facilities including multiple institutes at the National Institutes of Health (NIH) and other public and private organizations. 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Educational Benefits for Career Growth
  • Paid Time Off (Including Holidays)
  • Employee Referral Bonus
  • 401K Matching
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

Overview:

We are seeking a motivated Financial & Systems Analyst to support our finance and accounting operations while helping improve financial systems and processes. This role blends financial analysis with technology-driven process improvement to ensure accurate reporting, efficient workflows, and reliable decision-making support.

The ideal candidate has a strong foundation in financial principles, enjoys working with data, and is eager to learn new tools and systems. This position is based in Rockville, MD 5 days/week. 

Responsibilities:

  • Collect, organize, and analyze financial data to prepare accurate reports.
  • Assist with budgeting, forecasting, and variance analysis.
  • Support monthly, quarterly, and annual reporting cycles.
  • Help monitor company performance metrics and hihlight trends or discrepancies.
  • Work with accounting staff on reconciliations, general ledger support, and compliance with GAAP and FAR/DCAA requirements.
  • Support the use and optimization of financial systems including Deltek Vantagepoint and Microsoft Dynamics.
  • Create dashboards and reports in Power BI to track KPIs and financial performance.
  • Assist with automating workflows using Power Automate and other tools to reduce manual effort.
  • Help document financial processes and recommend improvements for efficiency and accuracy.
  • Collaborate with IT and Finance teams to troubleshoot system issues and support integrations.

Qualifications:

  • Bachelor’s degree in Finance, Accounting, Information Systems, or related field.
  • 2-4 years of experience in financial analysis, accounting, or systems/process improvement (internships or co-op experience welcome).
  • Familiarity with financial ERP systems (Deltek, Microsoft Dynamics, or similar).
  • Hands-on experience with Power BI, Excel, or automation tools is a plus.
  • Strong attention to detail and ability to analyze data for accuracy.
  • Excellent communication and collaboration skills.
  • Eagerness to learn and grow in both financial and systems-focused areas.
  • Ability to work in Rockville, MD 5 days/week 

This role is perfect for someone who wants to gain experience in both finance and financial systems while supporting process improvements and working closely with senior analysts and leadership.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process, please contact careers@axleinfo.com

Disclaimer: The above is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job or responsibilities as needed.

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

Salary Range
$80,000—$100,000 USD

Scientist – High Containment Laboratory

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a meticulous and innovative Scientist to join our team. The successful candidate will manage complex imaging equipment within high-containment laboratories and play a crucial role in planning and executing advanced animal imaging studies.

 

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

 

Responsibilities

  • Manage specialized imaging equipment within high-containment laboratory environments.
  • Plan and execute advanced animal imaging studies.
  • Design, execute, and analyze laboratory experiments with BSL-4 pathogens in accordance with project goals and safety standards. 
  • Deliver accurate interpretation and analysis of various imaging data types.
  • Advise on imaging technologies, equipment installation, maintenance, and upgrades.
  • Recommend appropriate imaging modalities for biological endpoints in studies with novel or highly pathogenic agents.
  • Collaborate on the design and execution of complex imaging studies.
  • Work with internal teams and external partners to ensure effective study design and data translation.
  • Support the introduction and review of new collaborative studies.
  • Assist in manuscript preparation for peer-reviewed publications in high-impact journals.
  • Prepare technical reports, recommendations, and plans related to imaging equipment and study designs.
  • Communicate research findings effectively through reports, presentations, and discussions.

 

Qualifications

  • PhD preferred, B.S. or M.S. in biomedical engineering, imaging sciences, or related discipline is required. 
  • Minimum of 3-5 years of direct hands on experience in a BSL-4 laboratory is required.
  • Ability to work with select agents under established biosafety and security protocols.
  • Demonstrated ability to work independently and as part of a multidisciplinary team.
  • Strong analytical and problem solving skills with a results-driven mindset. 
  • Commitment to safety, integrity, and excellent in research. 

 

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#INDPSD

 

Salary Range
$120,000—$140,000 USD

Pharmacoepidemiologist, Causal Inference

(ID: 2025-0803)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a talented Pharmacoepidemiologist to join our team to support projects at the NIH’s National Center for Advancing Translational Sciences (NCATS). In this role, you will collaborate with clinical and data scientists, methodologists, and software engineers to develop and execute exemplar causal inference studies. You will work as a subject matter expert to create a real-world evidence (RWE) methods decision tree; support master protocol development; and support development of gold-standard guides and methodologies for conducting best practices causal inference research. You will: design, execute, and analyze studies using the National Clinical Cohort Collaborative (N3C) data; review and recommend strategies for selecting study designs to answer causal inference questions; help establish, and implement appropriate analytic value sets. 

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

 

Overview:

The ideal candidate for the Pharmacoepidemiologist position is a highly skilled professional with a Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics, Causal Inference or related field. This person has experience with electronic health record and/or claims data and a strong understanding of observational study principles including: missing data handling methods; temporal research questions (cross-sectional, longitudinal); causal contrast of interest (e.g., intent-to-treat, per-protocol); effect measure of interest (e.g., risk ratio, hazard ratio); and estimands (e.g., average treatment effect, average treatment effect in the treated) of interest. Your research experience includes one or more of the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods, realized in multiple primary-author publications. Fluency with coding languages and tools is expected (i.e. SQL, Python, and R). 

 

Responsibilities: 

  • Serve as SME for RWE causal inference studies. 

  • Design and execute studies with N3C EHR data considering the following: extent of missing data; missing data handling methods; temporal component of research studies (i.e. cross-sectional, longitudinal); the causal contrast of interest (e.g., intent-to-treat, per-protocol); the effect measure of interest (e.g., risk ratio, hazard ratio); and estimand (e.g., average treatment effect, average treatment effect in the treated) of interest. 

  • Review and recommend strategies for selecting individuals in clinical cohorts. 

  • Ensure the highest data quality and minimization of bias. 

  • Use tools and languages such as Python, R, SQL, and Spark. 

  • Help establish and implement appropriate analytic value sets. 

  • Collaboratively produce extensive documentation (i.e. through training material, research protocols, open data sources such as repositories and/or methodological and research papers). 

  • Work closely with data science and software developer teams to articulate technical methods and implement decision tool strategies. 

  • Extract and transform clinical data from clinical trial and observational studies. 

  • Participate in project meetings, provide updates on progress, challenges, and mitigation strategies. 

  • Actively engage in key relevant meetings and keep abreast of emerging best practices and methods. 

 

Required Qualifications:

  • Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics or related field. 

  • Experience with the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods realized in at least 2 primary-author peer-reviewed publications, or equivalent. 

  • Ability to independently conduct statistical analysis with analytic software tools (e.g. Python, R, SQL, MatchIt/WeightIt, Matplotlib, Lifelines, SKLearn, GT-summary, statsmodels, Survey). 

  • Fluent in coding languages and tools (e.g. Python, R, SQL, Spark). 

  • Strong communication and collaboration skills, with the ability to work effectively in a multidisciplinary team. 

 

Preferred Qualifications:

  • Experience with meta-analyses and/or systematic reviews. 

  • Expertise in best practices for statistical approaches, data wrangling and visualization. 

  • Knowledge of FAIR data principles. 

  • Clinical informatics experience. 

 

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#INDPSD

Salary Range
$135,000—$140,000 USD

High-Performance Computing (HPC) Systems Engineer

(ID: 2025-0683)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a High-Performance Computing (HPC) Systems Engineer to join our vibrant team at the National Institutes of Health (NIH) supporting the The National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD.

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview: 

The High-Performance Computing (HPC) Systems Engineer will support the Scientific Computing and Informatics (SCI) team at The National Center for Advancing Translational Sciences (NCATS). This role will focus on the design, optimization, security, and maintenance of HPC and cloud-based infrastructures that enable cutting-edge biomedical research through scalable, secure, and high-performing computing environments. 

 

 

Responsibilities: 

  • Design, configure, and maintain scalable HPC clusters for optimal performance. 

  • Support documentation and ATO (Authority to Operate) processes. 

  • Ensure infrastructure design compliance with federal security standards and best practices. 

  • Implement monitoring tools such as XDMoD for transparency and user reporting. 

  • Integrate platforms such as JupyterHub and job schedulers (e.g., Slurm) for improved interactivity. 

  • Develop and manage AWS-based infrastructure using Terraform, Packer, and Ansible. 

  • Automate deployment workflows to streamline provisioning, updates, and scaling. 

  • Manage systems involved in AWS Secure Cloud Bridging (SCB) and STRIDES initiatives. 

  • Implement CIS benchmark-aligned system hardening using OpenSCAP. 

  • Administer optimized compute images (CPU/GPU) for scientific workflows. 

  • Leverage tools such as OpenHPC, Warewulf, and Ansible for environment management. 

  • Lead and coordinate quarterly patch cycles. 

  • Partner with researchers and external stakeholders on critical projects. 

  • Facilitate solution transitions to other NIH centers and collaborators. 

  • Contribute to publications and team objectives through deep technical engagement. 

 

 

Qualifications: 

  • Federal ATO processes experience required 

  • HPC architecture and performance optimization is required 

  • Scientific software development and deployment 

  • High-speed network and parallel file system architecture 

  • Troubleshooting, diagnostics, and technical support 

  • Strong communication and multitasking skills 

  • Programming & Scripting:  

  • Languages – Pascal, BASIC, Delphi, Visual Basic, C, C++ 

  • Scripting – Bash, Perl, Python, Ruby, PEAR, Tcl 

  • Systems & Network Administration:  

  • Linux – RHEL/CentOS, SUSE, Debian, Ubuntu 

  • Windows – 95–10; NT–Server 2016 

  • Networking – Active Directory, TCP/IP v4/v6, DHCP, DNS, WINS 

  • Legacy – NOVELL 3.1–5, VPN, Citrix, Terminal Services 

  • Monitoring & Management Tools:  

  • Nagios, Ganglia, HP BAC, Precise i3 

  • SGI SMC, HP PCM, Bright Cluster Manager (incl. Data Analytics) 

  • Infrastructure & Automation:  

  • Puppet, Cobbler, Ansible, Chef 

  • Red Hat Satellite, Kickstart, RPM optimization 

  • File Systems & Archiving:  

  • Panasas (DirectFlow/panfs), DDN (GPFS), SGI DMF, StorHouse/RFS (Filetek) 

  • HPC Tools & Job Scheduling:  

  • MOAB/MAUI, Torque, PBS Pro, Windows HPC Scheduler 

  • Visualization & Remote Access:  

  • Nice DCV, EnginFrame, VNC, OpenText Exceed OnDemand, Web Remote Desktop 

  • Containerization & GPU:  

  • Docker, Kubernetes, Kubeflow, NVIDIA DGX-1 GPU systems 

  • Databases:  

  • SQL Server (2000–2008), MySQL, Zope 

  • High-Speed Networking:  

  • Infiniband, Mellanox, OFED, Voltaire, Force10 

  • Proven experience in: 

  • HPC architecture and performance tuning 

  • Cybersecurity in HPC/cloud environments 

  • Infrastructure as Code (AWS, Terraform, Ansible, Packer) 

  • Supporting scientific workflows in research environments 

 

 

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#INDPSD

Salary Range
$150,000—$160,000 USD