Veterinarian Staff Scientist

(ID: 2025-1105)

 

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Benefits:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off (Including Holidays)
  • Employee Referral Bonus
  • 401K Match
  • Tuition reimbursement and professional development opportunities
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Axle is seeking a dynamic and dedicated Veterinarian Staff Scientist to join our team at The Division of Intramural Research (DIR) of the National Heart, Lung, and Blood Institute (NHLBI) to work in the Murine Phenotyping Core (MPC).

 

Environment:

The MPC is a full scale, busy, and in demand mouse phenotyping core that provides technical and scientific expertise for the phenotypic characterization of mouse models. We collaborate on projects with investigators across NIH on a diversity of mouse models utilizing state of the art equipment and comprehensive testing methodologies to assess multiple physiological and behavioral systems.

The core is equipped to handle all aspects of comprehensive, complex and diverse phenotyping projects in the areas of cardiovascular, metabolic, pulmonary, neuromuscular, behavioral phenotyping and exercise physiology testing while providing scientific consultation and collaboration with NIH research labs. The position offers diverse and exciting opportunities for interdisciplinary collaboration, development of comprehensive expertise in mouse phenotyping and comparative medicine, the ability to shape and steer ongoing growth of the core.

 

Overview:

Our team at NHLBI seeks an experienced candidate with a strong mouse research background to assist in both the technical, and scientific aspects involved in the core’s daily work and collaborations. In addition to performing mouse phenotyping study work in the core (50% of time), this candidate would have the scientific background required to work alongside core staff in areas including: scientific collaboration and communications with investigators, experimental design, data analysis and interpretation, and new method development. 

 

The candidate for the position is expected to be able to perform a variety of specialized in vivo mouse phenotyping techniques and have a strong background in comparative medicine and/or physiology. The candidate is expected to develop expertise in in-vivo murine testing including: neuromuscular and behavioral phenotyping on diverse models, exercise testing, muscle/nerve stimulation, cardiovascular system testing, pulmonary system testing, metabolic phenotyping, and microsurgery. The successful applicant will be expected to already be experienced conducting in vivo mouse research in multiple listed areas and would be expected to become proficient in all areas over time.

 

The individual would have the experiential and educational background required to read relevant scientific literature, and possess general understanding of physiology to develop the necessary knowledge in all areas serviced by the core (neuromuscular, behavioral, cardiovascular, pulmonary, exercise, and metabolic phenotyping of mouse models) in order to oversee scientific strategic testing planning, experimental design, data analysis and interpretation, and follow up testing suggestions for diverse mouse models with our NIH collaborators, as well as to independently develop new testing methods, validate or refine new or existing methods, and serve as a core liaison to provide educational outreach to scientists and students at NIH.

 

Responsibilities: 

  • Perform a variety of in vivo mouse phenotyping testing and methods. 
  • Understand applications of the core’s diverse phenotyping method repertoire and possess the ability to strategically apply testing strategies to target model specific questions.
  • Prepare summaries of experiments, contribute to the evaluation and discussion of results. Study, adapt, and/or develop new techniques needed to answer new research questions.
  • Maintain detailed records of laboratory experiments, perform statistical analysis of data, prepare tables, charts, graphs, summaries, and other materials for inclusion in publications.
  • Provide training and guidance to students, fellow and other staff members in the DIR in the use of equipment/laboratory methods, procedures, and techniques.
  • Contribute as an author and co-author in the writing and preparation of scientific papers for publication in recognized journals.
  • Attend training sessions for new methodologies and techniques as needed and participate in conferences to stay abreast of latest scientific developments.
  • Develop new methods and techniques independently where training does not exist by reviewing literature and applying own scientific knowledge, aptitude and insights to find new approaches to answering questions.

 

Qualifications:

 

Required

  • Exceptional candidates with a Master’s degree in an appropriate area of specialization and at least 5 years of mouse research experience with relevant hands on skill and proficiency conducting in vivo mouse testing will be considered.  Must have prior experience conducting technically complex experimental protocols. 
  • Candidate must be able to lift 40lbs weight, move quickly and quietly in small confined spaces, get up and down from ground easily, stand for extended periods of time.
  • Excellent written and oral communication skills.  Positive person with strong customer service mindset.
  • Proficient hands on technical abilities and mouse handling skills required.

 

Preferred

  • PhD degree in an appropriate area of specialization with experience working with mouse
  • models.
  • DVM or VMD with animal model research experience and/or transitioning into the research field.

 

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$120,000$140,000 USD

Cryo-Electron Microscopy Specialist

(ID: 2025-0868)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

 

Axle is seeking a Cryo-Electron Microscopy Specialist to join our vibrant team at the National Institutes of Health (NIH) supporting the National Institute of Allergy and Infectious Diseases (NIAID) located in Bethesda, MD.

 

Benefits We Offer:

  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

 

Overview
The highly skilled Cryo-Electron Microscopy (cryo-EM) Specialist will be joining the Research Technologies Branch (RTB), Electron Microscopy Unit (EMU) with the National Institute of Allergy and Infectious Diseases (NIAID) Division of Intramural Research (DIR). This position is based at the main NIH campus in Bethesda, Maryland, to support the primary cryo-EM operations at Rocky Mountain Laboratories (RML) in Hamilton, Montana. This role is pivotal in advancing biomedical research in the fields of immunology, parasitology, infectious disease, allergic disease, and vaccine development. The successful candidate will work as a team member to operate state-of-the-art instrumentation, with thorough knowledge of structural biology, providing access to cutting-edge cryo-EM technologies, designing and executing experiments, interpreting data, and ensuring the delivery of high-quality results.

 

Key Responsibilities

  • Consultation and Collaboration:
    • Engage with DIR investigators to discuss and plan new cryo-EM experiments.
    • Collaborate with scientists from other NIH Intramural Centers (ICs).
  • Project Management:
    • Oversee cryo-EM projects from DIR investigators and the Trans NIH cryo-EM initiative, NICE.
    • Coordinate specimen preparation, data collection, and processing for multiple simultaneous requests.
  • Experimental Design and Execution:
    • Develop experimental designs for protein purification and quality assessment in collaboration with DIR investigators and the RTB’s Structural Biology Unit (SBU).
    • Operate state-of-the-art cryo-EM instrumentation and a 120 kV microscope for screening negatively stained samples.
    • Establish cryo-workflow solutions for shipping of screened, frozen grids to RML for high-resolution data collection.
  • Training and Education:
    • Train DIR and NIH scientists on plunge freezing and microscope operations.
    • Educate students, postdocs, and investigators in cryo-EM specimen preparation, data collection, three-dimensional structural reconstructions, and data interpretation.
  • Data Analysis and Publication:
    • Collaborate with the NIAID RTB microscopy facility, RTB SBU, and Integrated Data Sciences Section (IDSS) on experimental design and data collection.
    • Assist in data interpretation and prepare tables, figures, and experimental details for publication.
    • Contribute to manuscript preparation for publication.
  • Budget and Instrumentation:
    • Acquire quotes and prepare budget requests for new instrumentation.
    • Engage with service providers to minimize instrument downtime.

 

Requirements

  • Ph.D. in chemistry, biochemistry, biology, or other relevant fields.
  • Relevant publication record.
  • Post-graduate experience in electron microscopy of proteins and/or infectious disease and immunology-associated samples is highly desirable.
  • Minimum of five years of experience operating Thermo Fisher Scientific 120 kV, 200 kV, and 300 kV cryo-electron microscopes.
  • Minimum of five years of experience reconstructing and generating models from cryo-EM data.
  • Experience in data management.
  • Excellent communication skills and ability to work in a team environment with co-workers whose expertise ranges from novice to expert.
  • Ability to advise and collaborate effectively with diverse laboratories.
  • Strong organizational and record-keeping skills.
  • Attend and present at national and international meetings.

 

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range
$100,000$110,000 USD